The core mental aspects of what makes us human has been a staple of science fiction films, particularly since the 1980s. Blade Runner examined what made an organic-creation a human, while the RoboCop series saw an android mechanism fitted with the brain and reprogrammed mind of a human to create a cyborg. The idea of brain transfer was not entirely new to science fiction film, as the concept of the "mad scientist" transferring the human mind to another body is as old as Frankenstein.
Films such as Total Recall have popularized a thread of films that explore the concept of reprogramming the human mind. The theme of brainwashing in several films of the sixties and seventies including A Clockwork Orange and The Manchurian Candidate coincided with secret real-life government experimentation during Project MKULTRA. Similarly, movies such as Equilibrium deal with drug-induced mind control along with dystopian control of human culture. The cyberpunk film Johnny Mnemonic used the reprogramming concept for a commercial purpose as the human became a data transfer vessel. Voluntary erasure of memory is further explored as themes of the films Paycheck and Eternal Sunshine of the Spotless Mind. In Dark City, human memory and the fabric of reality itself is reprogrammed wholesale. The anime series Serial Experiments Lain also explores the idea of reprogrammable reality and memory.
The idea that a human could be entirely represented as a program in a computer was a core element of the film Tron. This would be further explored in the film version of The Lawnmower Man, and the idea reversed in Virtuosity, Demon Seed and others as computer programs sought to become real persons. In the Matrix series, the virtual reality world became a real world prison for humanity, managed by intelligent machines. In eXistenZ, the nature of reality and virtual reality become intermixed with no clear distinguishing boundary. Likewise The Cell intermixed dreams and virtual reality, creating a fantasy realm with no boundaries.

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